Semaglutide: What to Expect
Semaglutide is a GLP-1 receptor agonist used for weight loss. It's administered as a once-weekly subcutaneous injection. This guide covers what to expect when starting, how the medication works, and what a typical treatment experience looks like.
How Semaglutide Works
Semaglutide mimics a natural hormone called GLP-1 (glucagon-like peptide-1) that regulates appetite and blood sugar. By acting on receptors in the brain and digestive system, it:
Reduces appetite and cravings
Slows digestion, helping you feel full longer
Helps regulate blood sugar response after meals
The result is a significant reduction in calorie intake that, combined with healthy habits, supports sustained weight loss.
Starting Dose and Titration
Semaglutide is started at a low dose—typically 0.25 mg weekly—to allow your body to adapt. Your provider selects your starting dose based on your health profile. Dose increases happen gradually over months, always under provider guidance.
Do not adjust your dose on your own. Contact the clinical team through your patient portal if you want to request a dose adjustment.
How to Inject
Injected subcutaneously (just under the skin) once weekly
Common injection sites: abdomen, upper thigh, or upper arm
Rotate injection sites to avoid tissue buildup
Can be taken at any time of day, with or without food
If you miss a dose by fewer than 5 days, take it as soon as possible; if more than 5 days have passed, skip and resume your regular schedule
What to Expect Month by Month
Month 1: Adjustment
Focus on tolerability. Nausea is the most common early side effect and typically peaks in the first 2–3 weeks. Appetite suppression usually becomes noticeable within the first week or two. Weight loss in month one averages 2–5 lbs.
Months 2–6: Building Progress
As your dose adjusts and your body adapts, most meaningful weight loss occurs during this phase. Side effects generally ease. You may find portion control becomes natural rather than effortful.
Long-Term
Semaglutide is designed for ongoing use. Consistent treatment combined with sustainable eating habits delivers the best outcomes over time.
Common Side Effects
Nausea — most common, usually improves within a few weeks
Constipation — increases with reduced food intake; stay hydrated
Fatigue — as your body adjusts to lower calorie intake
Headache or dizziness — usually temporary
If side effects are severe or persistent, contact your clinical team through your patient portal.
The medication Verge prescribes is a compounded version of semaglutide, not Ozempic® or Wegovy®. Compounded medications are not FDA-approved but are prepared by FDA-registered, state-licensed pharmacies based on your prescription.
Storage
Refrigerate your medication. Do not freeze. If your medication arrived at room temperature or warmer, contact support before using it.