I'm Experiencing Side Effects
Side effects are common when starting or adjusting GLP-1 medications and other treatments. Most side effects are manageable and improve as your body adapts. Here's what to expect and when to seek help.
Common Side Effects in the First Weeks
The most frequently reported side effects with GLP-1 medications include:
Nausea — the most common early side effect, often peaks in weeks 1–3
Constipation — often related to reduced food intake; staying hydrated helps
Fatigue — your body adjusting to lower calorie intake
Bloating or gas — typically mild and improves over time
Reduced appetite — this is the intended effect, but can feel abrupt early on
These side effects are dose-dependent—they tend to be more pronounced at higher doses and during dose increases. They typically improve within a few weeks as your body adjusts.
Tips to Manage Common Side Effects
Nausea: Eat smaller, lighter meals. Avoid large, fatty, or greasy foods. Stay hydrated. Inject on a schedule.
Constipation: Increase water intake. Eat fiber-rich foods. Light activity helps.
Fatigue: Make sure you're eating enough even if your appetite is reduced. Protein and electrolytes help.
When to Contact Your Provider
Reach out to the clinical team through your patient portal if you experience:
Side effects that are severe or persistent beyond 3–4 weeks
Vomiting that prevents you from keeping food or liquids down
Significant abdominal pain
Signs of dehydration (dizziness, dark urine, extreme fatigue)
Any side effect that concerns you or is affecting your daily life
Log in to your portal at app.startverge.com and send a message through the message center to the clinical team.
When to Seek Immediate Care
Go to urgent care or call 911 immediately if you experience:
Severe and persistent abdominal pain (possible pancreatitis)
Signs of a serious allergic reaction (difficulty breathing, swelling of face or throat)
Rapid or irregular heartbeat
Any symptoms you consider a medical emergency
Verge's platform is for non-emergent care. Emergency situations require immediate in-person medical attention.
Should You Adjust Your Dose?
Do not adjust your dose on your own. If side effects are making treatment difficult, contact your provider through the message center. They may recommend reducing your dose, staying at the current level for longer before increasing, or other adjustments. Provider-guided dose changes are safer and lead to better long-term outcomes.