NAD+: What to Expect

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in all living cells that plays a central role in energy metabolism, cellular repair, and aging. Verge offers NAD+ injections as part of its anti-aging and longevity program. This guide explains how NAD+ works and what to expect during treatment.

How NAD+ Works

NAD+ is essential for hundreds of metabolic reactions in the body. It powers energy production in cells and activates proteins (sirtuins) involved in cellular repair and inflammation regulation. Levels of NAD+ naturally decline with age, and this decline is associated with reduced energy, cognitive fog, and increased inflammation.

NAD+ injections deliver the coenzyme directly, bypassing the digestive system for more immediate availability at the cellular level.

Potential Benefits

Research and clinical use suggest NAD+ supplementation may support:

• Improved energy levels and reduced fatigue

• Enhanced mental clarity and focus

• Better cellular repair and resilience

• Support for healthy aging processes

Individual results vary. Some patients notice effects within days; others may need several weeks of consistent treatment to notice changes.

How to Inject

• Administered as a subcutaneous injection

• Your provider will specify the frequency and dosing schedule

• Rotate injection sites to avoid tissue buildup

• Follow the specific instructions included with your medication

What to Expect During Treatment

Early Period

Some patients experience a brief flush, warmth, or mild discomfort at the injection site when first starting. This typically resolves quickly. At higher doses or infusion rates, some patients experience nausea, headache, or flushing—usually short-lived.

Over Time

Consistent treatment tends to produce the most noticeable benefits after 4–8 weeks. Many patients report gradual improvements in energy, sleep quality, and mental sharpness.

Common Side Effects

• Mild injection site reactions (redness, warmth)

• Brief flushing or warmth sensation

• Headache (usually mild, temporary)

• Nausea (less common with subcutaneous injections vs. IV)

Storage

Refrigerate your NAD+ medication. Keep away from light. Follow any specific storage instructions included with your order.